GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs875971 | 1 | rs6460292 | chr7:65810075 | ASL | chr7:65540776-65558321:+ | 0.16 | 4.29 | 2.13E-5 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6460292 | chr7:65810075 | GUSB | chr7:65425675-65447246:- | -0.28 | -5.51 | 5.99E-8 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6460292 | chr7:65810075 | RABGEF1 | chr7:66093890-66276446:+ | -0.66 | -14.21 | 1.73E-38 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6460295 | chr7:65882728 | ASL | chr7:65540776-65558321:+ | -0.16 | -4.16 | 3.75E-5 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6460295 | chr7:65882728 | GUSB | chr7:65425675-65447246:- | 0.27 | 5.34 | 1.43E-7 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6460295 | chr7:65882728 | RABGEF1 | chr7:66093890-66276446:+ | 0.65 | 14.09 | 5.98E-38 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6460296 | chr7:65895139 | ASL | chr7:65540776-65558321:+ | -0.16 | -4.29 | 2.19E-5 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6460296 | chr7:65895139 | GUSB | chr7:65425675-65447246:- | 0.28 | 5.39 | 1.11E-7 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6460296 | chr7:65895139 | LOC729156 | chr7:66274980-66309813:- | 0.16 | 3.37 | 0.000811 | Aortic root size |
| THCA | cis | rs875971 | 1 | rs6460296 | chr7:65895139 | RABGEF1 | chr7:66093890-66276446:+ | 0.66 | 14.25 | 1.21E-38 | Aortic root size |
| THCA | cis | rs1801085 | 1 | rs6461985 | chr7:27150634 | HOXA9 | chr7:27202058-27205149:- | -0.37 | -4.16 | 3.85E-5 | Hypospadias |
| THCA | cis | rs62458065 | 1 | rs6462363 | chr7:32464759 | AVL9 | chr7:32535176-33079034:+ | -0.16 | -4.68 | 3.82E-6 | Metabolite levels (HVA/MHPG ratio) |
| THCA | cis | rs62458065 | 1 | rs6462364 | chr7:32464776 | AVL9 | chr7:32535176-33079034:+ | -0.16 | -4.68 | 3.82E-6 | Metabolite levels (HVA/MHPG ratio) |
| THCA | cis | rs4723738 | 1 | rs6462817 | chr7:38250865 | STARD3NL | chr7:38217933-38270269:+ | -0.53 | -12.48 | 3.93E-31 | Treatment response for severe sepsis |
| THCA | cis | rs11976180 | 1 | rs6464573 | chr7:143748098 | ARHGEF35 | chr7:143883677-143892736:- | 0.51 | 10.71 | 3.82E-24 | Obesity-related traits |